Synthesis and biological activity of prostaglandin lactones

GL Bundy, DC Peterson, JC Cornette…

Index: Bundy; Peterson; Cornette; Miller; Spilman; Wilks Journal of Medicinal Chemistry, 1983 , vol. 26, # 8 p. 1089 - 1099

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Citation Number: 31

Abstract

Most of the primary prostaglandins and several biologically important prostaglandin analogues were converted to 1, 9-, 1, ll-or 1, 15-lactones, in order to investigate the biological profiles of these internal esters and to assess their potential as prodrugs for the corresponding open-chain hydroxy acids. In each case, the key lactonization step was done using Corey's “double activation” procedure (cyclization of w-hydroxy-2-pyridinethiol ...