Preparation of N, N-Dimethyl-N′-Arylureas Using S, S-Dimethyl Dithiocarbonate as a Carbonylating Reagent

I Degani, R Fochi, C Magistris, M Migliaccio

Index: Degani, Iacopo; Fochi, Rita; Magistris, Claudio; Migliaccio, Mara Synthesis, 2009 , # 5 p. 801 - 808

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Citation Number: 3

Abstract

Abstract A new, general method for the preparation of N, N-dimethyl-N′-arylureas using S, S-dimethyl dithiocarbonate as a phosgene substitute is reported. The method has been set up according to four procedures, all including three steps:(1) reaction of S, S-dimethyl dithiocarbonate with dimethylamine to give S-methyl N, N-dimethylthiocarbamate;(2) halogenation with various halogenating reagents (chlorine, methanesulfenyl chloride, ...