Scavenging activity of aminoantipyrines against hydroxyl radical
…, AMM Antunes, J Noronha, E Fernandes…
Index: Santos, Pedro M.P.; Antunes, Alexandra M.M.; Noronha, Joao; Fernandes, Eduarda; Vieira, Abel J.S.C. European Journal of Medicinal Chemistry, 2010 , vol. 45, # 6 p. 2258 - 2264
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Citation Number: 29
Abstract
The pyrazolone derivatives antipyrine and 4-(N, N-dimethyl)-aminoantipyrine (aminopyrine) have long been used as analgesic, antipyretic and anti-inflammatory drugs. However, in spite of its recognized therapeutic benefits, the use of pyrazolones has been associated with agranulocytosis. Though the oxidation of aminopyrine by neutrophil-generated hypochlorous acid (HOCl), leading to the formation of a cation radical, has been ...
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