Antinociceptive Activity of Metamizol Metabolites in a Rat Model of Arthritic Pain
FJ López??Muñoz, O Soria??Arteche…
Index: Lopez-Munoz, Francisco Javier; Soria-Arteche, Olivia; Lopez, Jose Raul Medina; Hurtado Y De La Pena, Marcela; Garcia, Ma. Concepcion Lozada; Moreno-Rocha, Luis Alfonso; Dominguez-Ramirez, Adriana Miriam Drug Development Research, 2013 , vol. 74, # 5 p. 332 - 338
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Abstract
ABSTRACT The aim of the present study was to evaluate the antinociceptive activity of the main metamizol (MET) metabolites, 4-methylaminoantipyrine (MAA), 4-aminoantipyrine (AA), 4-formylaminoantipyrine (FAA), and 4-acetylaminoantipyrine (AAA) using the “pain- induced functional impairment in rat” model (PIFIR model). The antinociceptive efficacies of MAA and AA were 288.3% h and 281.1% h, respectively, close to the efficacy of MET ( ...
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