(2-Pyridyl) phenyl methanol: a new reagent for metal-free reduction of nitro aromatic compounds

D Giomi, R Alfini, A Brandi

Index: Giomi, Donatella; Alfini, Renzo; Brandi, Alberto Tetrahedron, 2011 , vol. 67, # 1 p. 167 - 172

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Citation Number: 11

Abstract

As previously reported for 1-(2-pyridyl)-2-propen-1-ol,(2-pyridyl) phenyl methanol is able to react as hydrogen donor towards nitro aromatic and heteroaromatic compounds. Operating in the presence of methyl acrylate as an aza-Michael acceptor, a domino process involving reduction and conjugate addition steps allows the one pot formation of β-amino esters. The crucial role of the pyridine nucleus in making this purely thermal reactivity of carbinols ...