An Efficient Synthesis of Racemic 4??Hydroxy??2??oxo??1??pyrrolidineacetamide (Oxiracetam) Using Tetramic??Acid Intermediates

DDP Laffan, M Bänziger, L Duc, AR Evans…

Index: Helvetica Chimica Acta, , vol. 75, # 3 p. 892 - 900

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Citation Number: 12

Abstract

... 24%). 33 Page 9. 900 HELVETICA CHIMICA ACTA - Vol. 75 (1992) Oxiracetam (1a)from Ammonolysis ofld. Ester Id (53.4 g, 248 mmol) was dissolved in EtOH/NH, (217 g of a 15% NH? ... Bull. 1982, 18, 165. [3] B. J. R. Nicolaus, Drug Development Res. 1982,2,463. ...

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