A new series of N2-substituted-5-(p-toluenesulfonylamino) phthalimide analogues as α-glucosidase inhibitors

X Bian, Q Wang, C Ke, G Zhao, Y Li

Index: Bian, Xiaoli; Wang, Qian; Ke, Changhu; Zhao, Guilan; Li, Yiping Bioorganic and Medicinal Chemistry Letters, 2013 , vol. 23, # 7 p. 2022 - 2026

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Citation Number: 2

Abstract

Several members of a new family of non-sugar-type α-glycosidase inhibitors, bearing a 5-(p- toluenesulfonylamino) phthalimide moiety and various substituent at the N2 position, were synthesized and their activities were investigated. The newly synthesized compounds displayed different inhibition profile towards yeast α-glycosidase and rat intestinal α- glycosidase. Almost all the compounds had strong inhibitory activities against yeast α- ...