RSC Advances

A one-pot process for palladium catalyzed direct C–H acylation of anilines in water using a removable ortho directing group

F Szabó, D Simkó, Z Novák

Index: Szabo, Fruzsina; Simko, Daniel; Novak, Zoltan RSC Advances, 2014 , vol. 4, # 8 p. 3883 - 3886

Full Text: HTML

Citation Number: 9

Abstract

A new mild, practical method for the synthesis of aminobenzophenone derivatives through a three step one-pot reaction sequence involving acylation of anilines, palladium catalyzed cross-dehydrogenative coupling of the formed anilides and the hydrolytic cleavage is reported. The full reaction sequence was performed under aqueous conditions.

Related Articles:

Synthesis of 2-aminobenzophenones via rapid halogen-lithium exchange in the presence of a 2-amino-N-methoxy-N-methylbenzamide

[Frye, Stephen V.; Johnson, Marty C.; Valvano, Nicole L. Journal of Organic Chemistry, 1991 , vol. 56, # 11 p. 3750 - 3752]

Synthesis of a new generation reverse transcriptase inhibitor via the BCl 3/GaCl 3-induced condensation of anilines with nitriles (sugasawa reaction)

[Houpis, Ioannis N.; Molina, Audrey; Douglas, Alan W.; Xavier, Lyndon; Lynch, Joseph; et al. Tetrahedron Letters, 1994 , vol. 35, # 37 p. 6811 - 6814]

Synthesis and biological evaluation of substituted 2-sulfonyl-phenyl-3-phenyl-indoles: a new series of selective COX-2 inhibitors

[Hu, Wenhui; Guo, Zongru; Chu, Fengming; Bai, Aiping; Yi, Xiang; Cheng, Guifang; Li, Jing Bioorganic and Medicinal Chemistry, 2003 , vol. 11, # 7 p. 1153 - 1160]

Synthesis and biological evaluation of substituted 2-sulfonyl-phenyl-3-phenyl-indoles: a new series of selective COX-2 inhibitors

[Hu, Wenhui; Guo, Zongru; Chu, Fengming; Bai, Aiping; Yi, Xiang; Cheng, Guifang; Li, Jing Bioorganic and Medicinal Chemistry, 2003 , vol. 11, # 7 p. 1153 - 1160]

Preparation of Recoverable Pd Catalysts for Carbonylative Cross??Coupling and Hydrogenation Reactions

[Niu, Jian-Rui; Huo, Xing; Zhang, Feng-Wei; Wang, Hai-Bo; Zhao, Ping; Hu, Wu-Quan; Ma, Jiantai; Li, Rong ChemCatChem, 2013 , vol. 5, # 1 p. 349 - 354]

More Articles...