Synthesis of 2-aminobenzophenones via rapid halogen-lithium exchange in the presence of a 2-amino-N-methoxy-N-methylbenzamide

SV Frye, MC Johnson, NL Valvano

Index: Frye, Stephen V.; Johnson, Marty C.; Valvano, Nicole L. Journal of Organic Chemistry, 1991 , vol. 56, # 11 p. 3750 - 3752

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Citation Number: 40

Abstract

2-Aminobenzophenones are important precursors to 1, 4-benzodiazepines.'The continued discovery of novel l, 4-benzodiazepines with new biological activities2 makes versatile routea for the synthesis of 2-aminobenzophenones essential to further investigations of the structure-activity relationships of these seemingly ubiquitous receptor ligand~.~