Acrolein mercapturates: synthesis, characterization, and assessment of their role in the bladder toxicity of cyclophosphamide

K Ramu, LH Fraiser, B Mamiya, T Ahmed…

Index: Ramu; Fraiser; Mamiya; Ahmed; Kehrer Chemical Research in Toxicology, 1995 , vol. 8, # 4 p. 515 - 524

Full Text: HTML

Citation Number: 60

Abstract

Acrolein is the metabolite of cyclophosphamide (CP) believed to be involved in the bladder toxicity associated with this anticancer drug. The mechanism by which this extremely reactive intermediate is delivered to the bladder is not known. Glutathione (GSH) readily conjugates with acrolein, and the acrolein mercapturate S-(3-hydroxypropyl)-N- acetylcysteine(3-hydroxy-PrMCA) has been found in the urine of animals and man given ...

Related Articles:

Homogeneous oxidation reactions of propanediols at low temperatures

[ChemSusChem, , vol. 3, # 9 p. 1063 - 1070]

Rubidium-and caesium-doped silicotungstic acid catalysts supported on alumina for the catalytic dehydration of glycerol to acrolein

[Journal of Catalysis, , vol. 286, p. 206 - 213]

Oxetene: synthesis and energetics of electrocyclic ring opening

[Journal of the American Chemical Society, , vol. 102, # 16 p. 5429 - 5430]

Synthesis of meso??and (±)??2, 2′??bis (carboxymethoxy) oxydiacetic acid via cis??and trans??2, 5??(diallyloxy)??2, 5??dihydrofuran: Model compounds for the calcium …

[Nieuwenhuizen, M.S.; Kieboom, A.P.G.; Bekkum, H. van Recueil: Journal of the Royal Netherlands Chemical Society, 1982 , vol. 101, # 10 p. 339 - 342]

Sensitized photo-oxygenation of acyclic conjugated dienes

[Matsumoto, Masakatsu; Dobashi, Satoshi; Kuroda, Keiko; Kondo, Kiyosi Tetrahedron, 1985 , vol. 41, # 11 p. 2147 - 2154]

More Articles...