Antibiotic activities and affinities for bacterial cell wall analogue of N-demethylvancomycin and its derivatives.

H Yan, D Qi, X Cheng, Z Song, W Li, B He

Index: Yan, Husheng; Qi, Dongfeng; Cheng, Xiaohui; Song, Zhengji; Li, Wenlan; He, Binglin Journal of Antibiotics, 1998 , vol. 51, # 8 p. 750 - 756

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Citation Number: 19

Abstract

N-Demethylvancomycin, which has been clinically used in China, is one member of vancomycin group (glycopeptide) antibiotics. It differs from vancomycin only in that methyl group on the amino group of the N-terminal residue of vancomycin has been replaced by H. By reductive alkylation of N-demethylvancomycin, we synthesized N-alkyl and N, N′-dialkyl N-demethylvancomycins, which closely correlated with vancomycin in structure. The ...