Optimization and Scale-Up of a Novel Process for 2-Aminoindan Hydrochloride Production
D Roche, D Sans, MJ Girgis, K Prasad…
Index: Organic Process Research and Development, , vol. 5, # 2 p. 167 - 175
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Abstract
... Detailed Procedure. ... It is important not to overheat the reaction mixture because of a decomposition process starting at 84 °C. Cool to 25 °C and add a slurry of 2.64 g of dry 10% Pd on activated carbon premixed with 77.40 g of glacial acetic acid ... Filter the top organic layer. ...
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