Optimization and Scale-Up of a Novel Process for 2-Aminoindan Hydrochloride Production
D Roche, D Sans, MJ Girgis, K Prasad…
Index: Roche, Didier; Sans, David; Girgis, Michael J.; Prasad, Kapa; Repic, Oljan; Blacklock, Thomas J. Organic Process Research and Development, 2001 , vol. 5, # 2 p. 167 - 175
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Abstract
The need for an economical process for producing 2-aminoindan hydrochloride, a key starting material in manufacturing novel bioactive molecules, motivated development of a novel synthetic route using an inexpensive reactant, ninhydrin. The synthesis, involving oximation of ninhydrin followed by catalytic reduction of the resulting oxime intermediate to give 2-aminoindan, was demonstrated successfully, and a product purification scheme ...
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