Efficient synthesis of the key intermediate triptophenolide methyl ether for the synthesis of (−)-triptolide
B Zhou, X Li, H Feng, Y Li
Index: Zhou, Bing; Li, Xiaomei; Feng, Huijin; Li, Yuanchao Tetrahedron, 2010 , vol. 66, # 29 p. 5396 - 5401
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Citation Number: 16
Abstract
An efficient synthesis of triptophenolide methyl ether 4 from the readily available abietic acid 3 in nine steps is described and successfully applied to the synthesis of (−)-triptolide 1. The route is of characteristic of low cost, high yield and easy operation. In addition, every reaction in this route has been successfully scaled-up to a 100g substrate level without loss of yield.
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