Synthesis of fused [1, 2, 6] thiadiazine 1, 1-dioxides as potential transition-state analog inhibitors of xanthine oxidase and guanase

RB Meyer Jr, EB Skibo

Index: Meyer,R.B.; Skibo,E.B. Journal of Medicinal Chemistry, 1979 , vol. 22, p. 944 - 948

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Citation Number: 19

Abstract

Ring closure of ethyl 3-aminopyrazole-4-carboxylate with sulfamoyl chloride gave 1, 7- dihydropyrazolo [3, 4-c][l,-2, 6] thiadiazin-4 (3H)-one 2, 2-dioxide. The corresponding 4- amino analogue of this new heterocyclic ring system was similarly prepared from 3- aminopyrazole-4-carbonitrile. Treatment of 4, 5, 6-triamino-2H-l, 2, 6-thiadiazine 1, l-dioxide with N-thionylaniline gave a derivative of another new ring system, 7-amino-4H-[1, 2, 5] ...