Bis (2-methoxyethyl) aminosulfur trifluoride: a new broad-spectrum deoxofluorinating agent with enhanced thermal stability

…, RJ Pesaresi, FM Prozonic, H Cheng

Index: Lal, Gauri S.; Pez, Guido P.; Pesaresi, Reno J.; Prozonic, Frank M.; Cheng, Hansong Journal of Organic Chemistry, 1999 , vol. 64, # 19 p. 7048 - 7054

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Citation Number: 273

Abstract

Bis (2-methoxyethyl) aminosulfur trifluoride,(CH3OCH2CH2) 2NSF3 (Deoxo-Fluor reagent), is a new deoxofluorinating agent that is much more thermally stable than DAST (C2H5) 2NSF3 and its congeners. It is effective for the conversion of alcohols to alkyl fluorides, aldehydes/ketones to the corresponding gem-difluorides, and carboxylic acids to the trifluoromethyl derivatives with, in some cases, superior performance compared to DAST. ...