Microwave-promoted hydroxycarbonylation in water using gaseous carbon monoxide and pre-pressurized reaction vessels

CM Kormos, NE Leadbeater

Index: Kormos, Chad M.; Leadbeater, Nicholas E. Synlett, 2006 , # 11 p. 1663 - 1666

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Citation Number: 33

Abstract

We decided to screen a range of substrates in the reaction using both 1 mol% Pd(OAc) 2 and 0.01 mol% palladium derived from our ICP standard. The results are shown in Table [2] . Only aryl iodides can be coupled using the methodology; aryl bromides are unreactive (Table [2] , entry 2). A range of aryl iodides can be converted to the benzoic acids including ortho-substituted examples (Table [2] , entries 10 and 11). Generally, product yields are higher when using ...