Journal of medicinal chemistry

Synthesis and enzymic activity of some new purine ring system analogs of adenosine 3'5'-cyclic monophosphate

G Sagi, K Szucs, G Vereb, L Otvos

Index: Sagi; Szucs; Vereb; Otvos Journal of Medicinal Chemistry, 1992 , vol. 35, # 24 p. 4549 - 4556

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Citation Number: 15

Abstract

A series of novel adenosine 3', 5'-cyclic monophosphate (CAMP) analogues, as well as their 6-deamino and 6-nitro derivatives, were synthesized where the purine ring was replaced by indazole, benzotriazole, and benzimidazole. The 3', 5'-cyclic monophosphates of indazole and benzotriazole ribofuranosides, where the sugar-phosphate moiety is attached to the N-2 nitrogen atoms of the heterocycles, were also prepared. The biological efficiency of the ...