Homogeneous Catalytic Hydrogenation of Amides to Amines

…, AMZ Slawin, DJ Cole??Hamilton

Index: Coetzee, Jacorien; Dodds, Deborah L.; Klankermayer, Juergen; Brosinski, Sandra; Leitner, Walter; Slawin, Alexandra M. Z.; Cole-Hamilton, David J. Chemistry - A European Journal, 2013 , vol. 19, # 33 p. 11039 - 11050

Full Text: HTML

Citation Number: 1

Abstract

Abstract Hydrogenation of amides in the presence of [Ru (acac) 3](acacH= 2, 4- pentanedione), triphos [1, 1, 1-tris-(diphenylphosphinomethyl) ethane] and methanesulfonic acid (MSA) produces secondary and tertiary amines with selectivities as high as 93% provided that there is at least one aromatic ring on N. The system is also active for the synthesis of primary amines. In an attempt to probe the role of MSA and the mechanism of ...