The addition of amines to diisobutylaluminum-imine complexes. Preparation of NPS R-568 Hydrochloride
RM Barmore, SR Logan, BC VanWagenen
Index: Barmore, Robert M.; Logan, Sarah R.; Van Wagenen, Bradford C. Tetrahedron Letters, 1998 , vol. 39, # 21 p. 3451 - 3454
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Citation Number: 14
Abstract
A facile procedure for the preparation of secondary and tertiary amines from nitriles has been developed. The addition of amines to diisobutylaluminum-imine complexes derived by treating nitriles with DIBAL-H was found to proceed in moderate to good yields and was used to prepare NPS R-568 (1) hydrochloride, a potent calcium receptor agonist.
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