Tetrahedron

The synthesis of 6-deoxyanthracyclinones:(±) α-citromycinone and (±) 4-demethoxy-6-deoxydaunomycinone

JS Swenton, DK Anderson, CE Coburn, AP Haag

Index: Swenton, John S.; Anderson, D. Keith; Coburn, Charles E.; Haag, Anthony P. Tetrahedron, 1984 , vol. 40, # 22 p. 4633 - 4642

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Citation Number: 9

Abstract

Two synthetic approaches have been explored to prepare 6-deoxyanthracyclinones in general and α-citromycinone in particular. The first approach employed as starting materials 1, 4, 5-trimethoxynaphthalene and the Diels-Alder product from butadie regioselective carbon acylation of 4-hydroxy-l, 5-dimethoxynaphthalene with the half-ester acid chloride of cis-4, 5-dicarboxycyclohexene. The resulting product was converted to 7, 10-dideoxy-α- ...

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