Oxidation products of arachidonic acid. IV. Model studies on the attachaient of the C (13)-C (20) side-chain in the synthesis of tetrahydrofurans and pyrans 1, 2, and 3

G Just, D Crosilla

Index: Just, George; Crosilla, Danilo Canadian Journal of Chemistry, 1980 , vol. 58, # 22 p. 2349 - 2357

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Citation Number: 10

Abstract

The synthesis of methyl 15-hydroxy-8 (R)-methoxy-11 (R)-p-nitrobenzoyloxy-9 (S), 12 (R)- oxy-eicosa-13-ynoate, an arachidonic acid metabolite derivative, is described. As well, methods for the attachment of the C (13)-C (20) prostaglandin side-chain to furanosides were studied and the results are described. The reduction of the C-15 keto group on a model compound was performed and was found to have the same behavior as in the ...