Asymmetric Syntheses of 8??Oxabicyclo [3, 2, 1] octanes: A Cationic Cascade Cyclization

B Li, YJ Zhao, YC Lai, TP Loh

Index: Li, Bin; Zhao, Yu-Jun; Lai, Yin-Chang; Loh, Teck-Peng Angewandte Chemie - International Edition, 2012 , vol. 51, # 32 p. 8041 - 8045

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Citation Number: 6

Abstract

Compelled by the interesting biological activities of 8-oxatropanes, many groups have embarked on the search for new methodologies to construct this bicyclic structure. For example, Molander and co-workers have reported a Lewis acid promoted double allylation of 1, 4-dicarbonyl compounds to construct 8-oxatropanes.[6] The same group later reported the syntheses of 8-oxatropanes using a TiCl4-promoted cycloaddition of a bis ( ...