Iridium??Catalyzed Asymmetric Hydrogenation of Unfunctionalized, Trialkyl??Substituted Olefins

A Wang, R Fraga, E Hörmann…

Index: Wang, Aie; Fraga, Rui P. A.; Hoermann, Esther; Pfaltz, Andreas Chemistry - An Asian Journal, 2011 , vol. 6, # 2 p. 599 - 606

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Citation Number: 11

Abstract

Abstract Chiral iridium complexes with bicyclic pyridine-based N, P ligands have emerged as efficient catalysts for the enantioselective hydrogenation of unfunctionalized trialkyl- substituted olefins. Optimization of the reaction conditions by variation of the solvent, pressure, and temperature led to enantiomeric excesses of up to 99%. Three pure alkenes,(E)-2-cyclohexyl-2-butene and (E)-and (Z)-3, 4-dimethyl-2-pentene were ...