Mechanism of. alpha.-ketoglutarate oxidation in coupled enzymic oxygenations
B Lindblad, G Lindstedt, M Tofft…
Index: Lindblad,B. et al. Journal of the American Chemical Society, 1969 , vol. 91, p. 4604 - 4606
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Citation Number: 50
Abstract
Model experiments in our laboratory have given support for a reaction mechanism of this type; eg, t-butyl alcohol and succinic acid are formed in the reaction between t-butyl hydroperoxide and a-ketoglutarate. To establish that molecular oxygen is incorporated into succinate in the enzyme reaction, as required by the above mechanism, we have carried out the hydroxylation of y-butyrobetaine in an lsOz-enriched atmosphere.
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