Poly (ethylene glycol)-supported proline: a versatile catalyst for the enantioselective aldol and iminoaldol reactions

…, M Cinquini, F Cozzi, A Puglisi, G Celentano

Index: Benaglia, Maurizio; Cinquini, Mauro; Cozzi, Franco; Puglisi, Alessandra; Celentano, Giuseppe Advanced Synthesis and Catalysis, 2002 , vol. 344, # 5 p. 533 - 542

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Citation Number: 188

Abstract

Abstract:(2S, 4R)-4-Hydroxyproline has been anchored to the monomethyl ether of poly (ethylene glycol), MW 5000, by means of a succinate spacer to afford a soluble, polymer- supported catalyst (PEG-Pro) for enantioselective aldol and iminoaldol condensation reactions. This organic catalyst can be considered as a minimalistic version of a typeI aldolase enzyme, with the polymer chain replacing the enzyme◊ s peptide backbone, and ...