Helvetica Chimica Acta

A Novel Trypsin??Catalyzed Three??Component Mannich Reaction

SJ Chai, YF Lai, H Zheng, PF Zhang

Index: Chai, She-Jie; Lai, Yi-Feng; Zheng, Hui; Zhang, Peng-Fei Helvetica Chimica Acta, 2010 , vol. 93, # 11 p. 2231 - 2236

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Citation Number: 19

Abstract

Abstract We found that the trypsin from hog pancreas displayed high activity to promote three-component Mannich reaction of aromatic aldehydes, aromatic amines, and acetone with moderate-to-excellent yields. The reaction tolerates a great range of substrates and extends the application of trypsin in organic synthesis.