Palladium??Catalyzed Allylic Alkylation of Carboxylic Acid Derivatives: N??Acyloxazolinones as Ester Enolate Equivalents

…, DJ Michaelis, J Charpentier, J Xu

Index: Trost, Barry M.; Michaelis, David J.; Charpentier, Julie; Xu, Jiayi Angewandte Chemie - International Edition, 2012 , vol. 51, # 1 p. 204 - 208

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Citation Number: 23

Abstract

The asymmetric alkylation of carbonyl compounds is one of the most important methods for generating stereocenters in organic synthesis.[1] The alkylation of ester enolates is particularly useful as the resulting products can be converted into a variety of carboxylic acid derivatives or reduced to alcohols without loss of enantioenrichment at the α center.[2] The most common procedures for asymmetric ester enolate alkylations, however, involve the ...