Tandem copper-catalysed aryl and alkenyl amination reactions: the synthesis of N-functionalised indoles

RC Hodgkinson, J Schulz, MC Willis

Index: Hodgkinson, Roy C.; Schulz, Jurgen; Willis, Michael C. Organic and Biomolecular Chemistry, 2009 , vol. 7, # 3 p. 432 - 434

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Citation Number: 41

Abstract

The development of palladium catalysed aryl C–N coupling reactions employing aryl halides as substrates has had an enormous impact on synthetic chemistry. The wide range of N-based coupling partners, the ability to employ iodo-, bromo-, chloro- and sulfonate-substituted arenes as substrates, together with the availability of commercial catalysts are all responsible for the popularity and utility of this class of transformation. 1 More recently, copper-based ...