Convergent Functional Groups. 16. Hydrolysis of Phosphate Triesters by a Novel Cleft. Influence of Binding on Overall Rate Acceleration

BL Tsao, RJ Pieters, JJ Rebek

Index: Tsao, Belinda L.; Pieters, Roland J.; Rebek Jr., Julius Journal of the American Chemical Society, 1995 , vol. 117, # 8 p. 2210 - 2213

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Citation Number: 22

Abstract

Abstract: The rates of hydrolysis of two activated phosphate triesters, bis (p-nitrophenyl) methyl phosphate 3 and adenosine 5'-O, O-bis@-nitrophenyl) phosphate 4 have been studied using two copper-containing catalysts, Cu (Kempbpy) 1 and Cu (bpy) 2. The catalytic activities of these two species have been compared within the pH range of 6-9.5. The rates of hydrolysis of both substrates, 3 and 4, have been compared to the uncatalyzed reaction. ...