Tetrahedron letters

Combined directed metalation-cross coupling strategies. A regiospecific route to heteroring-annelated artho-naphthoquinones and a short synthesis of β-lapachone

MAF Brandão, AB de Oliveira, V Sneickus

Index: Brandao, Marcos A. F.; Oliveira, Alaide Braga de; Snieckus, Victor Tetrahedron Letters, 1993 , vol. 34, # 15 p. 2437 - 2440

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Citation Number: 43

Abstract

Abstract A general combined metalation-cross coupling methodology (Scheme 1) for the regiospecific construction of heteroring fused o-naphthoquinones 8 is described and its application to a short synthesis of the antimalarial/antitumor natural product β-lapachone (14) is demonstrated.

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