Furo [3′, 2′: 3, 4] naphtho [1, 2-d] imidazole derivatives as potential inhibitors of inflammatory factors in sepsis

…, CS Lin, PK Shih, LT Tsao, JP Wang, CM Cheng…

Index: Tseng, Chih-Hua; Lin, Chang-Sheng; Shih, Pin-Keng; Tsao, Lo-Ti; Wang, Jih-Pyang; Cheng, Chih-Mei; Tzeng, Cherng-Chyi; Chen, Yeh-Long Bioorganic and Medicinal Chemistry, 2009 , vol. 17, # 18 p. 6773 - 6779

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Citation Number: 41

Abstract

Synthesis and anti-inflammatory effects of certain furo [3′, 2′: 3, 4] naphtho [1, 2-d] imidazole derivatives 12–18 were studied. These compounds were synthesized from naphtho [1, 2-b] furan-4, 5-dione (10) which in turn was prepared from the known 2-hydoxy- 1, 4-naphthoquinone (7) in a one pot reaction. Furo [3′, 2′: 3, 4] naphtho [1, 2-d] imidazole (12) was inactive (IC50 value of> 30μM) while its 5-phenyl derivative 13, with an IC50 ...