Organic & biomolecular chemistry

Polymer-supported syntheses of thiophene-containing compounds using a new type of traceless linker

A Ben-Haida, P Hodge

Index: Ben-Haida, Abderrazak; Hodge, Philip Organic and Biomolecular Chemistry, 2012 , vol. 10, # 9 p. 1754 - 1763

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Abstract

A new type of traceless linker is described for use in polymer-supported (PS) syntheses of thiophene-containing compounds. It is based on the cleavage of PS aryl 2-thienyl ketones by a mixture of potassium t-butoxide and water (typical mol ratio 10: 3) in an ethereal solvent. Cleavage occurs to give the soluble thiophene-containing product. The method is used to prepare a range of eight thiophene-containing compounds including a ...

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