Synthesis and SAR evaluation of 1, 2, 4-triazoles as A 2A receptor antagonists

A Alanine, L Anselm, L Steward, S Thomi…

Index: Alanine, Alexander; Anselm, Lilli; Steward, Lucinda; Thomi, Stefan; Vifian, Walter; Groaning, Michael D. Bioorganic and Medicinal Chemistry Letters, 2004 , vol. 14, # 3 p. 817 - 821

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Citation Number: 39

Abstract

The neurotransmitter adenosine interacts with four G-protein coupled receptors the A 1 , A 2A , A 2B and A 3 receptors. 1 The A 2A receptor, which is Gs coupled, is of particular interest in the area of psychiatry research with high receptor densities found to be located in the dopamine-rich areas of the striatum and nucleus accumbens. 2 More recently A 2A receptors have been shown to be co-localized and interact with both dopamine D 2 and ...