Single??Step Microwave??Mediated Synthesis of Oxazoles and Thiazoles from 3??Oxetanone: A Synthetic and Computational Study

…, ZA Harrison, M Campbell??Crawford…

Index: Orr, David; Tolfrey, Alexandra; Percy, Jonathan M.; Frieman, Joanna; Harrison, Zoe A.; Campbell-Crawford, Matthew; Patel, Vipulkumar K. Chemistry - A European Journal, 2013 , vol. 19, # 29 p. 9655 - 9662

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Citation Number: 5

Abstract

Abstract The direct microwave-mediated condensation between 3-oxetanone and primary amides and thioamides has delivered moderate to good yields of (hydroxymethyl) oxazoles and (hydroxymethyl) thiazoles. The reactions use a sustainable solvent and only require short reaction times. These are highly competitive methods for the construction of two classes of valuable heteroarenes, which bear a useful locus for further elaboration. ...