2, 4-Dinitrophenol as an activating reagent in a facile preparation of cyclic phosphate triesters

EJ Amigues, ME Migaud

Index: Amigues, Eric J.; Migaud, Marie E. Tetrahedron Letters, 2004 , vol. 45, # 5 p. 1001 - 1004

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Citation Number: 12

Abstract

2, 4-Dinitrophenol was employed with benzyloxy-bis-(diisopropylamino) phosphine to synthesise the cyclic phosphate derivatives of a series of alkane diols (HO–(CH2) n–OH, n= 2–6) in good isolated yields. Tetrazole and DNP were compared by 31P NMR spectroscopy for their ability to catalyse the cyclisation at the P (III) stage. Investigation of the phosphate triester stability under various oxidation and chromatographic conditions resulted in the ...