In vitro antifungal activity of new series of homoallylamines and related compounds with inhibitory properties of the synthesis of fungal cell wall polymers

…, VV Kouznetsov, SN López, M Sortino, RD Enriz…

Index: Vargas M., Leonor Y.; Castelli, Maria V.; Kouznetsov, Vladimir V.; Urbina G., Juan M.; Lopez, Silvia N.; Sortino, Maximiliano; Enriz, Ricardo D.; Ribas, Juan C.; Zacchino, Susana Bioorganic and Medicinal Chemistry, 2003 , vol. 11, # 7 p. 1531 - 1550

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Citation Number: 130

Abstract

The synthesis, in vitro antifungal evaluation and SAR studies of 101 compounds of the 4-aryl- , 4-alkyl-, 4-pyridyl or-quinolinyl-4-N-arylamino-1-butenes series and related compounds, are reported here. Active structures showed to inhibit (1, 3)-β-d-glucan and mainly chitin synthases, enzymes that catalyze the synthesis of the major fungal cell wall polymers.