Manganese-catalyzed substitution of activated aryl halides (X= Cl, Br and F) and aryl ethers by organomagnesium reagents
G Cahiez, F Lepifre, P Ramiandrasoa
Index: Cahiez, Gerard; Lepifre, Franck; Ramiandrasoa, Parfait Synthesis, 1999 , # 12 p. 2138 - 2144
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Citation Number: 93
Abstract
Abstract: In the presence of manganese chloride (10%), Grignard reagents readily react in THF with aryl bromides, chlorides and even fluorides, as well as aryl methyl ethers bearing in the ortho-or para-position an electron withdrawing activating group (CN, CH= NR, oxazoline). Aryl and N-or S-alkylmagnesium halides have been used successfully. The reaction is performed under mild conditions (0 C to room temperature, 30 minutes to 24 ...
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