Preparation of novel unsymmetrical bisindoles under solvent-free conditions: Synthesis, crystal structures, and mechanistic aspects

HM Kaiser, I Zenz, WF Lo, A Spannenberg…

Index: Kaiser, Hanns Martin; Zenz, Ivo; Wei, Fun Lo; Spannenberg, Anke; Schroeder, Kristin; Jiao, Haijun; Goerdes, Dirk; Beller, Matthias; Man, Kin Tse Journal of Organic Chemistry, 2007 , vol. 72, # 23 p. 8847 - 8858

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Citation Number: 36

Abstract

Indole aziridines and their hydroxyl derivatives have been used for the preparation of a small library of novel functionalized bisindoles. Diversification of these building blocks by solvent-free CC-bond formation on solid support yielded annulated Hymenialdisine analogues under mild reaction conditions. Indoles as C-nucleophiles form potentially pharmacologically active bisindoles through an electrophilic aromatic substitution ...