Efficient catalytic promiscuity for chemically distinct reactions
…, S Bandyopadhyay, LF Olguin…
Index: Babtie, Ann C.; Bandyopadhyay, Subhajit; Olguin, Luis F.; Hollfelder, Florian Angewandte Chemie, International Edition, 2009 , vol. 48, # 20 p. 3692 - 3694
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Citation Number: 41
Abstract
Abstract High catalytic proficiencies observed for the native and promiscuous reaction of the Pseudomonas aeruginosa arylsulfatase (PAS; the picture shows transition states of the two substrates with corresponding binding constants K tx) suggest that the trade-off between high activity and tight specificity can be substantially relaxed.
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