Pressure-induced cyclotrimerization of electron-deficient nitriles. Catalysis by acidic alcohols and phenols

WM Koppes, HG Adolph

Index: Koppes, William M.; Adolph, Horst G. Journal of Organic Chemistry, 1981 , vol. 46, # 2 p. 406 - 412

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Citation Number: 12

Abstract

Results The use of the usual catalyst methanol for the highpressure trimerization of 1 was first explored since the preparation of methyl fluorodinitroacetimidate (3) in 50% yield from 1 and methanol had been reported.'In our experience, this reaction is strongly affected by the presence of water in the methanol which catalyzes an unidentified exothermic process leading to the evolution of some COz and the destruction of 1; care is therefore required to ...