Organic letters

Regioselective 1, 4-conjugate addition of grignard reagents to nitrodienes in the presence of catalytic amounts of Zn (II) salts

RC Dhakal, RK Dieter

Index: Dhakal, Ramesh C.; Dieter, R. Karl Organic Letters, 2014 , vol. 16, # 5 p. 1362 - 1365

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Citation Number: 6

Abstract

Grignard reagents undergo facile regioselective 1, 4-conjugate addition to nitrodienes in the presence of catalytic amounts of Zn (II) salts with excellent yields. A wide range of ligands such as alkyl, aryl, heteroaryl, allyl, vinyl, 1-alkynyl, and alkoxy ligands were transferred, while a thiolate ligand afforded 1, 6-regioselectivity. The reactions were successfully carried out on δ-alkyl-or aryl-substituted α, β, γ, δ-diunsaturated nitrodiene substrates. ...