Pd-catalyzed carbonylative reactions of aryl iodides and alkynyl carboxylic acids via decarboxylative couplings

A Park, K Park, Y Kim, S Lee

Index: Park, Ahbyeol; Park, Kyungho; Kim, Yong; Lee, Sunwoo Organic Letters, 2011 , vol. 13, # 5 p. 944 - 947

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Citation Number: 53

Abstract

Alkynyl carboxylic acids reacted with aryl iodides under a CO atmosphere in the presence of a palladium catalyst to produce α, β-alkynyl aryl ketones in good yields. The maximum turnover number was 16 800. The desired carbonylative coupling was formed from phenyl propiolic acid without any formation of a noncarbonylative coupling product in the absence of CuI. However, the reaction with alkyl-substituted alkynyl carboxylic acids required CuI ...