Stretch-induced biodegradation of polyelectrolyte multilayer films for drug release
…, MH Metz-Boutigue, B Senger, JC Voegel, P Schaaf…
Index: Davila, Johanna; Chassepot, Armelle; Longo, Johan; Boulmedais, Fouzia; Reisch, Andreas; Frisch, Benoit; Meyer, Florent; Voegel, Jean-Claude; Mesini, Philippe J.; Senger, Bernard; Metz-Boutigue, Marie-Helene; Hemmerle, Joseph; Lavalle, Philippe; Schaaf, Pierre; Jierry, Loic Journal of the American Chemical Society, 2012 , vol. 134, # 1 p. 83 - 86
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Citation Number: 24
Abstract
The design of stimuli-responsive polymer assemblies for the controlled release of bioactive molecules has raised considerable interest these two last decades. Herein, we report the design of mechanically responsive drug-releasing films made of polyelectrolyte multilayers. A layer-by-layer (LbL) reservoir containing biodegradable polyelectrolytes is capped with a mechanosensitive LbL barrier and responds to stretching by a total enzymatic degradation ...