Synthesis of 2-arylbenzoxazoles via the palladium-catalyzed carbonylation and condensation of aromatic halides and o-aminophenols
RJ Perry, BD Wilson, RJ Miller
Index: Perry, Robert J.; Wilson, B. David; Miller, Richard J. Journal of Organic Chemistry, 1992 , vol. 57, # 10 p. 2883 - 2887
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Citation Number: 55
Abstract
A new synthetic method is reported in which 2-arylbenzoxazoles can be prepared by the palladium-catalyzed condensation of aryl halides with o-aminophenols followed by dehydrative cyclization. This method is tolerant of a wide variety of functional groups on either aromatic ring and gives good to excellent yields of products. An aliphatic vicinal amino alcohol gave a bis-acylated product as well as a chlorine-containing product with only a ...
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