Synthesis of N-propynyl analogues of peptide nucleic acid (PNA) monomers and their use in the click reaction to prepare N-functionalized PNAs

NM Howarth, J Ricci

Index: Howarth, Nicola M.; Ricci, Jennyfer Tetrahedron, 2011 , vol. 67, # 49 p. 9588 - 9594

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Citation Number: 6

Abstract

Application of the click reaction for coupling a 2-(2-aminoethoxy) ethoxy (AEE) function to thyminyl, cytosinyl and adeninyl peptide nucleic acid (PNA) monomer analogues bearing a N-propynyl group, in place of the original N-2-aminoethyl moiety, has been explored. The N- propynyl PNA analogues were prepared from glycine ethyl ester hydrochloride and the structure of the thyminyl derivative was confirmed by X-ray diffraction. These monomers ...