Convenient modification of the Leimgruber-Batcho indole synthesis: reduction of 2-nitro-β-pyrrolidinostyrenes by the FeCl 3–activated carbon–N 2 H 4∙ H 2 O system
…, TY Dutova, EN Sidorenko, SS Krasnoselsky
Index: Taydakov; Dutova; Sidorenko; Krasnoselsky Chemistry of Heterocyclic Compounds, 2011 , vol. 47, # 4 p. 425 - 434
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Abstract
A new catalytic system containing ferric chloride, activated carbon, and hydrazine has been proposed for the reductive cyclization of β-dialkylamino-2-nitrostyrenes to give the corresponding indoles (Leimgruber-Batcho synthesis). Various substituted indoles may be obtained in high yield under these conditions.
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