A general synthesis of enantiopure 1, 2-aminoalcohols via chiral morpholinones

F Segat-Dioury, O Lingibé, B Graffe, MC Sacquet…

Index: Tetrahedron, , vol. 56, # 2 p. 233 - 248

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Citation Number: 18

Abstract

... Tetrahedron. Volume 56, Issue 2, 7 January 2000, Pages 233–248. ... c) 9a (X=Cl, R=CH 2 CO 2 CH 3 ) (1.1 equiv.), KI (0.1 equiv.), CH 3 CN or DMF, rt, 15 h. d) H 2 , 1 atm, 10% Pd/C, CH 3 CO 2 CH 3 , rt, 6 h. e) (i) HBr (9 equiv.) in CH 3 CO 2 H, rt, 30 min; (ii) solid K 2 CO 3 . ...