A general synthesis of enantiopure 1, 2-aminoalcohols via chiral morpholinones

F Segat-Dioury, O Lingibé, B Graffe, MC Sacquet…

Index: Segat-Dioury, Fabienne; Lingibe, Olivier; Graffe, Bernadette; Sacquet, Marie-Claude; Lhommet, Gerard Tetrahedron, 2000 , vol. 56, # 2 p. 233 - 248

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Citation Number: 18

Abstract

The most direct synthesis of optically active 1,2-aminoalcohols is the reduction of natural α-aminoacids or derivatives, 7 but this method is limited by the nature of lateral chains and optical antipode. Other racemic methods coupled with enzymatic 8a or chemical 8b resolution have thus been developed, providing a greater variety of 1,2-aminoalcohols. ... Few stereoselective preparations have been reported. The synthesis of optically active 2-amino-1- ...