A facile [hydroxy (tosyloxy) iodo] benzene mediated synthesis of 2-arylimidazo [1, 2-a] pyrimidines and their conversion into 3-bromo-2-arylimidazo [1, 2-a] pyrimidines

R Aggarwal, G Sumran

Index: Aggarwal, Ranjana; Sumran, Garima Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 2006 , vol. 45, # 12 p. 2690 - 2695

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Abstract

Abstract:-Tosyloxyketone 2, obtained through hypervalent iodine oxidation of enolizable ketones using [hydroxy (tosyloxy) iodo] benzene (HTIB) in acetonitrile, on treatment with 2- aminopyrimidine 3 generates regioselectively 2-arylimidazo [1, 2-] pyrimidine 6 which upon subsequent treatment with bromine undergoes electrophilic substitution at position-3 to yield 3-bromo-2-arylimidazo [1, 2-] pyrimidine 8.

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